| Product Group | : | Antibacterials |
| Pharmaceutical Form | : | Suspension for Injection |
| Active Ingredient | : | Cefalexin Monohydrate |
| Target Type | : | Cattle, Cat, Dog |
| Package Form | : | 100 ml |
For Animal Use Only
For Animal Use Only
Suspension for Injection
Veterinary Systemic Antibacterial
Maxef Suspension for Injection is cream-light pink in color and contains Cephalexin monohydrate equivalent to 180 mg of Cephalexin base per ml.
Cephalexin is a first-generation broad-spectrum cephalosporin with activity against Gram (+) and some Gram (-) bacteria. It is bactericidal. It shows this effect by inhibiting mucopeptide synthesis in the bacterial cell wall. Like other beta-lactam antibiotics, it also acts by inhibiting enzymes involved in bacterial cell wall syntheses, such as carboxypeptidase, transpeptidase, and endopeptidase in the bacterial cytoplasm.
Main bacterial species it is effective on Staphylococcus sp. (including penicillinase-producing strains), Streptococcus sp., Escherichia coli, Corynebacterium sp., Pasteurella multocida, Proteus sp., Micrococcus sp., Erysipelothrix rusiopathiae, Clostridium sp., Salmonella sp., Moraxella sp., Actinobacillus sp. Haemophilus sp., Fusobacterium sp., Peptostreptococcus sp., and Peptococcus sp.
It is rapidly absorbed from the injection site following intramuscular administration and reaches a maximum plasma concentration of 9.8 mg/ml within 1 hour. In order to see the bactericidal effect of cephalexin, the presence of an inhibitory concentration for two hours is sufficient. Its concentration in plasma drops rapidly and falls below the minimum limits after 12 hours. This rapid decrease in concentration prevents the antibiotic from accumulating in the blood-udder barrier and leaving residue in the milk. After metabolizing cephalexin, most of it is excreted in the urine and some in the feces.
Maxef Suspension for Injection is used as a complement to treatment for respiratory, digestive, and urogenital system infections, foot rot, interdigital infections, septicemia, skin and soft tissue infections, metritis and septicemic mastitis, intramammary infections caused by Gram (+) and Gram (-) microorganisms sensitive to cephalexin in cattle, cats and dogs.
Unless recommended otherwise by the veterinarian, it is administered subcutaneously or intramuscularly in cattle, cats, and dogs. The syringe to be used must be dry and sterile.
Pharmacological dose:
For cattle: 7 mg / kg body weight / day
For Cats - Dogs: 10 mg / kg body weight / day.
Practical dose:
For cattle: 1 ml / 25 kg live weight
For Cats and Dogs: 0.25 ml / 4.5 kg body weight. The bottle should be shaken well before use.
One application is made per day and the application is continued for 5 days. When the amount given exceeds 10 ml, the injection should be divided into two. The injection site should be massaged after application.
It is recommended to be used together with an appropriate intramammary antibiotic in septicemic mastitis. Dose adjustment should be made in animals with hepatic and renal impairment.
Susceptible animals may experience difficulty breathing, swelling of the tongue, redness of the mucous membranes and skin, and itching. Diarrhea, mucus in the stool or signs of bleeding may be observed.
In intramuscular administration, a temporary, local, mild tissue reaction may occur at the injection site. Anaphylactic reactions may occur in allergic animals.
It should not be used together with tetracyclines, phenicols and macrolides. It can have a synergistic effect when used with penicillins. There is cross-sensitivity with other cephalosporins.
Neurotoxic and nephrotoxic effects, abdominal cramps, drowsiness, and muscle spasms may occur depending on the high dose given and the prolongation of the duration. It may cause skin rashes and fever at the injection site. With the discontinuation of the application, the symptoms return to normal.
Drug Residue Elimination Period: During the treatment and 4 days after the last drug administration, cattle should not be sent to slaughter. The residue purification period for milk is “0” days.
It should not be used intravenously and intratracheally. It should not be used in animals hypersensitive to cephalosporins. It should not be used in animals with severe renal impairment.
Use in Pregnancy: Cephalosporins are known to cross the placenta, but studies in pregnant mice and rats did not reveal any teratogenic effects in the fetus.
Consult your veterinarian before use and in case of unexpected effects. Keep out of reach of children. Keep away from foodstuff.
Do not buy or use products with damaged packaging.
Penicillins and cephalosporins can cause serious allergic reactions by injection, inhalation, ingestion, or skin contact. Therefore, it is inconvenient for hypersensitive people to contact the product. If reactions such as itching are observed on the skin after contact, a physician should be consulted for medical intervention. Swelling of the face, lips, and tongue and shortness of breath are symptoms that require immediate medical attention.
It should be stored in its original packaging at 8 °C -25 °C, protecting it from direct sunlight. Shelf life is 2 years from the date of manufacture.
Maxef Suspension for Injection is offered for sale in 20 ml, 50, 100 ml transparent colored glass bottles and 100, 250 ml plastic bottles with cardboard boxes, and 500 ml plastic bottles without cardboard boxes.
Sold in veterinary clinics and pharmacies with a veterinarian's prescription.
T.R. MINISTRY OF AGRICULTURE AND FORESTRY MARKETING PERMISSION DATE AND NO 13.12.2011 – 25/018
Pİ FARMA İLAÇ SAN. VE TİC. A.Ş.
Malıköy Başkent OSB Mah. 26. Cad. No: 34/A - Sincan - ANKARA - TÜRKİYE
FDN İLAÇ Sanayi ve Ticaret Limited Şirketi
Büyükkayacık OSB Mahallesi, Reisköy Caddesi, İnsu Sokak, No: 3 Selçuklu / KONYA
