Nes-AD3E®

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Product Group	:	Vitamins
Pharmaceutical Form	:	Solution for Injection
Active Ingredient	:	Vitamin A Palmitate, Vitamin D3 (Cholecalciferol), Vitamin E Acetate
Target Species	:	Cattle, Horse, Sheep, Goat
Package Form	:	50 - 100 - 250 ml

For Veterinary Use Only

Composition - Pharmacological Properties
Indications – Usage
Undesirable Effects – Warnings

For Veterinary Use Only

Nes-AD3E®

Solution for Injection

Veterinary Vitamin

COMPOSITION

It is a clear yellow sterile solution containing 105,000 IU Vitamin A (Palmitate), 52,500 IU Vitamin Dз (Cholecalciferol) and 50 mg Vitamin E (Acetate), 18 mg benzyl alcohol as a preservative and 5 mg butylhydroxytoluene as an antioxidant in each ml.

PHARMACOLOGICAL PROPERTIES

NES-AD₃E Solution for Injection is a formulation containing vitamins A, Dз and E. It shows high bioavailability by being absorbed for a long time after intramuscular injection. It reaches the highest level in the blood in a short time. It also continues its protective and therapeutic effect by being stored in the liver.

Vitamin A: Provides regeneration and normal function of epithelial tissue, increases body resistance against infectious diseases, provides growth. Supports protein, carbohydrate and fat metabolism. Prevents night blindness. In case of deficiency; integrity of epithelial tissues is disrupted, hyperkeratosis type disorder occurs. When administered orally; It is absorbed by diffusion from small intestine epithelial cells and reaches peak concentration in plasma approximately 4 hours later. Its amount in plasma decreases to the extent that it is stored in the liver. Absorption continues in the intestines until the concentration in the liver reaches the peak point (2 mg/kg/c.a.). The unabsorbed part is excreted in the stool.

Vitamin Dз: Regulates calcium and phosphorus metabolism and increases their biological use. It ensures the development and hardening of skeletal tissue and the formation and strengthening of egg shells in poultry. In case of deficiency; calcium-phosphorus metabolism is disrupted. Bone and skeletal disorders such as rickets and osteomalacia occur. When administered orally, it is fully absorbed from the digestive tract. Absorbed Vitamin D3 first enters the lymphatic circulation and binds to lipoprotein and passes into the bloodstream. Plasma half-life is approximately 20-25 hours. It is stored in all tissues, especially fat tissue.

Vitamin E: Vitamin E ensures the development and normal functioning of genital organs. Facilitates fertilization and pregnancy. Regulates carbohydrate and creatinine metabolism. Supports development and growth. Increases hatchability. With its antioxidant properties, it plays a role in neutralizing freely circulating oxygen groups. It prevents the oxidation of fatty acids, which are the building blocks of cell membranes containing more than one fat in their structures, and extends their biological half-life. At the same time, thanks to its antioxidant mechanism, it ensures the durability of the cell membrane. After application, Vitamin E is first absorbed into the bloodstream and then stored in all body tissues.

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AREA OF USE/INDICATIONS

It is used to eliminate the deficiencies of vitamins A, Dз and E in cattle, sheep, goats and horses and treatment of diseases related to the deficiencies of these vitamins; providing the increased vitamin needs in the treatment of rickets in young animals, bone diseases and osteomalacia in adults due to vitamin D deficiency.

USAGE AND DOSAGE

Pharmacological dose;

Vitamin A: 2.625 IU/kg body weight,

Vitamin D3:1.310 IU/kg body weight

Vitamin E:1,25 mg/kg body weight.

It is administered intramuscularly and subcutaneously according to the following dosage table;

Animal Type	NES-AD₃E Solution for Injection	Application Method
Cattle	5 – 10 ml	Intramuscular
Horse	5 – 10 ml	Intramuscular
Calf, Heifer	2,5 – 5 ml	Intramuscular
Calf, Foal	2 – 3 ml	Intramuscular
Sheep, Goat	1 – 2 ml	Subcutaneous
Lamb – kid goat	0,5 – 1 ml	Subcutaneous

The application can be repeated every 2-3 months to prevent vitamin deficiency. The period can be shortened further in the treatment of vitamin deficiency. Application intervals can be changed according to the target species, care-feeding conditions and degree of deficiency.

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SPECIAL CLINICAL INFORMATION AND SPECIAL WARNINGS FOR TARGET SPECIES

Drug applications for versatile productivity enhancing, protective and treatment purposes can be repeated once a month depending on the dosage. Drug applications are planned for 7-8 weeks before the breeding season in breeding animals. When applied in the last 1/3 of pregnancy, it supports the healthy development of the offspring.

UNDESIRED EFFECTS

A small swelling may occur at the injection site and it disappears after a short time.

DRUG INTERACTIONS

Since there is no information on the incompatibility of Vitamin A (Palmitate), Vitamin Dз and Vitamin E (Acetate) with other drugs, they should not be used together with other veterinary products.

SYMPTOMS OF OVERDOSE, PRECAUTIONS AND ANTIDOTE

High doses of vitamin Dз and long-term administration can lead to the release of calcium and phosphorus from bones, thus increasing the level of these ions in the bloodstream. As a result, calcification can occur in some soft tissues and organs. If vitamin A is used excessively, it can cause hypervitaminosis. Intervention should be made with antihistamines, corticosteroids or atropine.

WITHDRAWAL PERIODS

Meat: “0” days

Milk: “0” days

CONTRAINDICATIONS

It is no contraindications when used as recommended dose.

GENERAL WARNINGS

Consult your veterinarian before use and in case of an unexpected effect. Keep out of reach of children.

PRECAUTIONS TO BE TAKEN BY THE ADMINISTRATOR AND WARNINGS FOR VETERINARY SURGEON

It contains benzyl alcohol as an antimicrobial. Asepsis and antisepsis rules must be followed during application. A sterile syringe must be used. It is recommended that the stopper not be pierced more than 20 times after the first use. Avoid direct contact with the product. If you accidentally inject yourself, seek medical treatment immediately and show the product leaflet to your doctor. Pregnant women should not apply this product due to the vitamin A content and the risk of self-injection.

STORAGE CONDITIONS AND SHELF LIFE

Store in the original packaging at room temperature (15˚C-25˚C). Protect from direct sunlight, do not refrigerate or freeze. Shelf life is 2 years. It should be consumed within 28 days after first use.

DISPOSAL AFTER USE AND WARNINGS FOR NON-TARGET SPECIES

Any used veterinary medicinal product or its residual material should be disposed of in accordance with local regulations.

COMMERCIAL PRESENTATION FORMS

It is offered for sale in 50 ml, 100 ml and 250 ml amber colored type II glass vials with boxes.

PLACE AND CONDITIONS OF SALE

Sold with Veterinary Surgeon’s prescription in pharmacies and veterinary surgeries (VSP).

APPROVAL DATE OF PACKAGE INSERT: 21.12.2021

MARKETING AUTHORIZATION DATE AND NO: 17.01.2019 - 028/0035

MARKETING AUTHORIZATION HOLDER

Pİ FARMA İLAÇ SAN. VE TİC. A.Ş.

Malıköy Başkent OSB Mah. 26. Cad. No:34/A Sincan/Ankara-Türkiye

MANUFACTURER COMPANY