Klifos B12®

Product Group	:	Vitamins
Pharmaceutical Form	:	Solution for Injection
Active Ingredient	:	Vitamin B12 (Cyanocobalamin), Butafosfan
Target Type	:	Cattle, Horse, Sheep, Goat
Package Form	:	50 - 100 - 250 ml

For Animal Use Only

Composition - Pharmacological Properties
Indications – Usage
Undesirable Effects – Warnings

For Animal Use Only

KLİFOS B₁₂

Solution for Injection

Veterinary Mineral-Vitamin

COMPOSITION

Klifos- B₁₂ Solution for Injection is a pink colored clear, sterile solution containing 100 mg of Butaphosphan (corresponding to 17.30 mg of phosphorus) and 0.05 mg of Vitamin B₁₂ per ml.

PHARMACOLOGICAL PROPERTIES

Butaphosphan ([1-(butyl amino)-1-methylethyl]-phosphonic acid) contained in Klifos-B12 Solution for Injection is an organic phosphorus compound with a high rate of evaluable phosphorus and used as a phosphorus source in various animal species. Phosphorus, one of the most important minerals involved in cellular activity, is the most important component of adenosine triphosphate (ATP), which provides cellular energy. Besides, it is one of the most important structural minerals of bone tissue along with calcium. It also plays a role in keeping the body’s pH in balance by acting as a buffer in blood and urine.

Butaphosphan is rapidly absorbed from parenteral administration points, reaching the highest plasma concentrations in a short time. It is distributed throughout the body and, shortly after stimulating the body's metabolic functions, leaves the body with urine via the kidneys.

Vitamin B₁₂ is a water-soluble B group essential vitamin that is necessary for the maintenance of carbohydrate, protein, and fat metabolism, the synthesis of individual amino acids, and the realization of various metabolic events. Among its important known functions is the production of erythrocytes which carry the necessary oxygen to the tissues to be used in the production of energy and ATP in the body, stimulating growth and preserving the integrity of the nervous tissues with its effects on the nervous system. In vitamin B12 deficiency, regression in growth and development, anemia, decrease in feed efficiency, and decrease in fertility is observed in all animal species. In animals, hypersensitivity, movement disorders, limitation of movement in the extremities, ataxia, and demyelination of peripheral nerves are observed, which reflects nervous disorders.

Vitamin B₁₂ is well absorbed after parenteral administration and reaches peak blood concentrations within 1 hour. Orally administered Vitamin B12 is absorbed from the digestive tract by active transport and simple diffusion, but an intrinsic factor in gastric secretion is required for absorption to occur. It turns into three types of coenzymes in the body. Vitamin B12 is excreted from the body with bile and urine. 70% of the amount excreted in the bile is reabsorbed by the enterohepatic route.

AREA OF USE/INDICATIONS

Klifos-B₁₂ Solution for Injection, as a therapeutic treatment in diseases shaped due to the deficiency of phosphorus and Vitamin B12 in its main formulation, in the downer-cow syndrome that can be seen in cattle towards the end of winter and in spring, loss of appetite, chronic indigestion, and rumen fullness, It is used in malnutrition, decrease in milk yield, metabolic disorders manifested by nervous symptoms and lumbago of horses.

- It is used in order to support the main treatment of diseases and developmental delays of newborns, metabolic disorders as a result of faulty care and nutrition, low productivity and anemia, nervous system diseases,

-To support calcium and magnesium treatment in tetany and paresis cases due to calcium, phosphorus, and magnesium metabolism disorders,

- in chronic diseases, extreme fatigue, exhaustion, weakness, after racing in racehorses and after overworking in power animals to support metabolism.

USAGE AND DOSAGE

Unless recommended otherwise by the veterinarian, Klifos-B₁₂ Solution for Injection is administered at a dose of 5 mg/kg by intravenous, subcutaneous, and intramuscular routes. Based on that, the amount of drug to be applied according to the animal species is as follows:

Practical dose table

In acute diseases;

Animal Type	Dose (ml)
Horse, cattle	5 - 25 ml
Foal, calf	5 - 12 ml
Sheep, goat	2.5 - 5 ml
Lamb, kid	1.5 - 2.5 ml
Dog	0.5 - 5 ml
Cat	0.5 - 2.5 ml

In chronic diseases:

Half of the recommended doses above are administered. If necessary, repetitions can be made every 1-2 weeks or at shorter intervals. Half of the above doses are administered to healthy animals to increase productivity.

SPECIFIC CLINICAL INFORMATION AND WARNINGS FOR TARGET SPECIES

Intravenous administration should be done under aseptic conditions. Care should be taken not to leak the drug into extravascular tissues during intravenous administration.

UNDESIRED EFFECTS

In rare cases of hypersensitivity reactions, adrenaline should be used.

DRUG INTERACTIONS

It should not be mixed with other drugs. There is no incompatibility with other drugs when administered with different injectors.

SYMPTOMS OF OVERDOSE, PRECAUTIONS, AND ANTIDOTE

Overdose can cause kidney stones. In case of poisoning, animals experience severe abdominal pain and vomiting in animals that can vomit. If left untreated, convulsions, coma, and death occur. Symptomatic treatment is applied in the treatment of phosphorus toxicity.

RESIDUAL WARNINGS FOR FOOD PRODUCING ANIMALS

Drug Residue Elimination Period: It is “0” days for meat and milk.

CONTRAINDICATIONS

No known contraindications

Use during pregnancy: It is safe to use during pregnancy.

GENERAL PRECAUTIONS

Consult your veterinarian before use and in case of an unexpected effect. Keep out of reach of children.

PRECAUTIONS TO BE TAKEN AND RECOMMENDATIONS FOR PHYSICIANS

Hands should be washed after use.

STORAGE CONDITIONS AND SHELF LIFE

Protect from light. Store at room temperature (15-25oC). Shelf life is 2 years from the date of manufacture. It maintains its effectiveness for 28 days in its original packaging and recommended storage conditions from the first use.