| - | - | - |
|---|---|---|
| Product Group | : | Vitamins |
| Pharmaceutical Form | : | Solution for Injection |
| Active Ingredient | : | Ascorbic Acid |
| Target Type | : | Cattle, Horse, Cat, Dog |
| Package Form | : | 50 ml |
For Animal Use Only
For Animal Use Only
VİTCE
Solution for Injection
Veterinary Vitamin
COMPOSITION
Vitce is a clear colorless to yellow colored sterile solution containing 200 mg ascorbic acid per ml.
PHARMACOLOGICAL PROPERTIES
Pharmacodynamic Properties
The ascorbic acid contained in Vitce Solution for Injection is essential for the formation and maintenance of the integrity of mesenchymal tissues (such as connective tissue, bone, cartilage, and dentin). It facilitates the conversion of pyrroline and lysine residues into hydroxypyroline and hydroxylysine in the specified tissues. This process is extremely important in collagen synthesis. Therefore, the most prominent function of ascorbic acid is its role in collagen biosynthesis. This vitamin also plays a role in the synthesis of corticosteroids in the adrenal cortex, the conversion of folic acid to folinic acid, and tyrosine metabolism. It also has an antitoxin effect against certain toxins.
Pharmacokinetics Properties
When administered parenterally to domestic animals, ascorbic acid is distributed throughout all tissues, including intracellularly. It binds to plasma proteins to a low degree. It is found in higher concentrations in leukocytes and platelets than in plasma and erythrocytes. Similarly, its concentration in glandular tissues is higher than in muscle and adipose tissues. It is stored in the body to a limited extent. Ascorbic acid is first converted to dehydroascorbate in the body and then reduced within the cell. Ascorbic acid is excreted in urine, sweat, and feces. Urine contains numerous ascorbic acid metabolites, such as dehydroascorbic acid, diketogulonic acid, ascorbate-2-sulfate oxalate, methyl ascorbate, and 2-ketoascorbital.
USE OF AREA / INDICATIONS
It is used in cattle, horse, dog and cat;
-Treatment of vitamin C deficiency,
-Used as a supportive treatment for fatigue, especially during periods of infection and stress.
USAGE AND DOSAGE
Vitce is administered to animals intramuscularly or intravenously.
The dosages given below are general recommendations. The required dosage may be adjusted by the veterinarian depending on factors such as the condition of the animals and their feeding patterns. The product cap can be punctured up to 30 times.
|
Species |
Pharmacological Dose |
Practical Dose |
Administration Route |
Administration Frequency |
|
Cattle |
4-6 mg/kg |
7-12 ml/day |
Intramuscular, intravenous |
Twice in a week during 3-6 weeks |
|
Horse |
5-10 mg/kg |
10-20 ml/day |
Intramuscular, intravenous |
Until the desired effect is achieved |
|
Dog |
25-500 mg/kg |
0,3-2,5 ml/day |
Intramuscular, intravenous |
Until the desired effect is achieved |
|
Cat |
25-75 mg/kg |
0,3-0,6 ml/day |
Intramuscular, intravenous |
Until the desired effect is achieved |
SPECIAL CLINICAL INFORMATION AND SPECIAL WARNINGS FOR TARGET SPECIES
With frequent administration, vomiting, diarrhea, frequent urination, formation of calcium oxalate crystals in the renal tubules, and petechial redness of the skin may be observed.
Use during pregnancy, lactation: As no teratogenicity studies have been conducted in animals, vitamin C should only be used during pregnancy if necessary.
ADVERSE EFFECTS
No side effects are known when used at the recommended doses. Ascorbic acid is a strong reducing agent. It may affect the results of numerous laboratory tests based on oxidation-reduction reactions, primarily the urine glucose test. Mild irritation may occur at the injection site.
DRUG INTERACTIONS
It may cause acidification of urine, thereby reducing the effectiveness of certain antibiotics such as aminoglycosides and erythromycin in urine. It should not be mixed with calcium-containing serums. It is incompatible with drugs containing heavy metal salts such as copper salts, iron salts, and oxidizing agents, and therefore should not be used together. When taken above 10 mg daily, ascorbic acid reduces the absorption of anticoagulant drugs such as coumarin and indandione derivatives from the gastrointestinal tract. High doses of vitamin C can render vitamin B12 ineffective.
It should not be mixed with other medicinal products.
SYMPTOMS OF OVERDOSE, PRECAUTIONS AND ANTIDOTE
When administered in high doses and frequently, it may cause urolithiasis (kidney stones), vomiting, diarrhea, frequent urination, formation of calcium oxalate crystals in the renal tubules, and petechial rash on the skin. Symptomatic treatment is administered in cases of overdose.
WITHDRAWAL PERIODS
‘0’ day for meat and milk.
CONTRAINDICATIONS
It should not be used in patients suspected of having urolithiasis (kidney stone formation).
GENERAL WARNINGS
Consult your veterinarian before use and in case of an unexpected effect. Keep out of reach of children and foodstuff.
PRECAUTIONS TO BE TAKEN BY THE ADMINISTRATOR AND WARNINGS FOR VETERINARY SURGEON
Do not eat or drink anything during application. Pay attention to aseptic and antiseptic rules. Do not touch the product. Wear protective gloves (disposable nitrile protective gloves) during application and wash your hands afterwards.
In case of eye contamination or excessive skin contact, rinse thoroughly with cold running water. If irritation persists, seek medical attention.
STORAGE CONDITIONS AND SHELF LIFE
Before and after opening, it should be stored below 25˚C, in the original package without being frozen and refrigerated, protect from light. Shelf life is 3 years. It should be consumed in 28 days after opening.
COMMERCIAL PRESENTATION FORM
50 ml amber colored glass flacons with box.
PLACE AND CONDITIONS OF SALE
Sold with Veterinary Surgeon’s prescription in pharmacies and veterinary surgeries.
APPROVAL DATE OF LEAFLET: 21.02.2025
MARKETING AUTHORIZATION DATE AND NO: 27.03.2000 - 009/0890
MARKETING AUTHORIZATION HOLDER
Pİ FARMA İLAÇ SAN. VE TİC. A.Ş.
Malıköy Başkent OSB Mah. 26. Cad. No:34/A Sincan/Ankara – Türkiye
MANUFACTURER COMPANY
FDN İLAÇ SAN. VE TİC. LTD. ŞTİ.
Büyükkayacık OSB Mah. İnsu Sokak No:3 Selçuklu/Konya – Türkiye
Made in Turkiye
