Şeritab®

-	-	-
Product Group	:	Parasiticides
Pharmaceutical Form	:	Oral Tablet
Active Ingredient	:	Praziquantel
Target Species	:	Horse, Sheep, Dog
Package Form	:	50 Tablet

For Veterinary Use Only

Composition - Pharmacological Properties
Indications – Usage
Undesirable Effects – Warnings

For Veterinary Use Only

ŞERİTAB®

Oral Tablet

Veterinary Anthelmintic

COMPOSITION

It is a yellow colored tablet with two break points containing 300 mg praziquantel per tablet.

PHARMACOLOGICAL PROPERTIES

Şeritab Oral Tablet contains praziquantel, an isoquinoleine derivative antihelminthic. Praziquantel is a broad-spectrum cestocidal antihelminthic specific to tapeworms. Praziquantel disrupts the tapeworm's membrane permeability, blocking glucose uptake and depleting its energy reserves, leading to the parasite's death. Within a few seconds of contact with praziquantel, intense spasms and contractions occur in the segments of the tapeworm, disrupting the function of the hooks embedded in the intestine, and the scolex leaves the mucosa and becomes paralyzed.

After administration, the product is largely absorbed from the stomach and intestine, reaching maximum serum levels within 30 minutes to 4 hours. It localizes in organs such as the liver and kidneys. The serum half-life is 4 hours, and excretion occurs mainly in the urine and, to a lesser extent, in the feces. Prazikuantel is completely eliminated from the body 8-10 hours after administration. Prazikuantel does not bind irreversibly to body tissues.

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AREA OF USE / INDICATIONS

It is used for the treatment of Taeniasis in sheep, horse and dog.

Sheep; Moniezia expansa, M. benedeni, Thysaniezia ovilla, Avitellina centripunctata, Stilesia globipunctata and S. hepatica (bile duct strip),

Horse; intestinal segments Anaplocephala sp. and Anaplocephaloides mamillana,

Dog; It exhibits potent anthelmintic activity against cestodes of the species Echinococcus granulosus, E. multilocularis, Diphylidium caninum, Taenia ovis, Taenia psiformis, T. hydatigena, Multiceps multiceps, Mesocestoides sp. and T. reniformis.

Since Şeritab Oral Tablet is effective against adult tapeworms, juveniles, and scolex, it is suitable for total tapeworm eradication. Şeritab Oral Tablet is used to eliminate clinical signs of chronic Coenurus cerebralis in sheep.

USAGE AND DOSAGE

The pharmacological dose of Şeritab Oral Tablet required for the elimination of young and adult tapeworms is 15 mg praziquantel/kg body weight in sheep, 1 mg/kg b.w. in horses, and 5-10 mg/kg b.w. in dogs. The tablets can be divided in half for administration. In cases of delibaş disease (Coenurus cerebralis) and against peritoneal cysticercos (Cysticercus tenuicollis), administering 50-100 mg/kg bw for 2-5 consecutive days reduces the symptoms of chronic Coenurus cerebralis.

Practical Dose Table;

Species	Tablet number
Goat (20 kg)	1
Sheep (50 kg)	2,5
Horse (according to body weight)	2-3
Dog (less than 15 kg)	0,5
Dog (between 15-30 kg)	1

Tablets should be swallowed with plenty of water. For tapeworm treatment, the application can be repeated after 6-8 weeks if necessary. In horses, it should be administered via a nasal syringe.

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SPECIAL CLINICAL INFORMATION AND SPECIAL WARNINGS FOR TARGET SPECIES

Because of the mechanism of action of praziquantel (depolarization, contraction, vacuolization, and shortening of the tapeworm), it is not always possible to see the tapeworms intact in the stool after administration of the Şeritab Oral Tablet. As a result of partial fragmentation and absorption of the tapeworms in the intestines, they may appear dissolved (like a thread or membrane), bead-like, or capsule-like, especially in hard stools. There is no need to any special diet on animals before using the Şeritab Oral Tablet or to use a purgative after treatment. Praziquantel is an antihelminthic with a high safety margin. It has not caused any side effects even at doses of 100-150 mg/kg in sheep. Sheep act as intermediate hosts for the larval forms (Coenurus cerebralis (delibaş disease) and Cysticercus tenuicollis) of the tapeworms Multiceps multiceps and Taenia hydatigena found in dogs. Therefore, it is important to treat dogs for tapeworms.

ADVERSE EFFECTS

In rare cases, abdominal pain, loss of appetite, nausea, vomiting, or diarrhea may occur.

DRUG INTERACTIONS

When used simultaneously with dexamethasone, the plasma concentration of praziquantel is reduced by half.

SYMPTOMS OF OVERDOSE, PRECAUTIONS AND ANTIDOTE

Tremors and convulsions may be observed in cases of overdose.

Symptomatic treatment should be administered. There is no specific antidote.

WITHDRAAL PERIODS

Meat: “0” (zero) day. Milk cannot be used for dairy sheep offered for human consumption.

CONTRAINDICATIONS

There are no known contraindications.

Use during pregnancy: Safe for use in pregnant animals at the recommended doses.

GENERAL WARNINGS

Consult your veterinarian before use and in case of an unexpected effect. Keep out of reach of children and food-stuff.

PRECAUTIONS TO BE TAKEN BY THE ADMINISTRATOR AND WARNINGS FOR VETERINARY SURGEON

The tapeworm eggs shed after treatment are a source of infection for mites in the soil. The feces produced after treatment must be thoroughly destroyed.

STORAGE CONDITIONS AND SHELF LIFE

It should be stored below 25°C, protect from light. Shelf life is 2 years.

COMMERCIAL PRESENTATION FORM

50 (10x5) tablets in blister with boxes.

PLACE AND CONDITIONS OF SALE

Sold with Veterinary Surgeon’s prescription in pharmacies and veterinary surgeries (VSP).

APPROVAL DATE OF LEAFLET: 01.04.2026

MARKETING AUTHORIZATION DATE AND NO: 28.03.2012 - 025/0082

MARKETING AUTHORIZATION HOLDER

Pİ FARMA İLAÇ SAN. VE TİC. A.Ş.

Malıköy Başkent OSB Mah. 26. Cad. No:34/A Sincan/Ankara-Türkiye

MANUFACTURER COMPANY